2 edition of Roles of p53 and p16 tumor suppressor genes in the cellular response to ultraviolet light found in the catalog.
Roles of p53 and p16 tumor suppressor genes in the cellular response to ultraviolet light
Mai Abudullah Fahad Al-Mohanna
Written in English
|Statement||Mai A. F. Al-Mohanna.|
|Series||Sussex theses ; S 5633|
|The Physical Object|
|Pagination||xvi, various pagings :|
Process of cellular senescence. In response to cellular damage, the cell activates a myriad of pathways including the pp21 and pRB tumor suppressor pathways for transient cell-cycle arrest to handle and repair the stress. If the damage is repaired, it can re-enter the cell-cycle. Abstract. p53 is one of the tumor suppressor genes found to be mutated in great majority of human cancers. The protein product of p53 gene is a nuclear phosphoprotein with characteristic features of a transcription factor acting on different target genes in order Author: Mehmet Öztürk, Kezban Unsal.
UV response of mammalian p53 tumor suppressor gene _____ 3 ORIGINAL PUBLICATIONS The thesis is based on the following original articles, which are referred to in the text by their Roman numerals. I Haapajärvi, T., Kivinen, L., Pitkänen, K., and Laiho, M. Cell cycle dependent. Inactivation of the INK4a/ARF (or CDKN2a) locus is a common and critical genetic event in the development of human and mouse melanoma. This locus engages the Rb and p53 tumor suppressor pathways Cited by:
The loss of the tumor suppressor gene product p16 in melanoma is well documented, although the normal physiological function of p16 in skin melanocytes is unknown. In this report, we demonstrate that when human skin was irradiated with suberythemal doses of UV radiation, levels of p16 were dramatically increased by 16 h postirradiation, peaking at 24 h, and declining by 72 h. p16 was Cited by: Mutations of p53, a tumor suppressor gene, are known to be involved in the pathogenesis of a number of neoplasms. Findings support the hypothesis that p53 mutations are homogeneous throughout a tumor and may thus be a more useful diagnostic and prognostic indicator than the expression of p53, which does not reliably correlate with p53 mutations.
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Roles of p53 and p16 tumor suppressor genes in the cellular response to ultraviolet light. Thesis (Thesis) Find all citations by this author (default). The role of the tumor suppressors p53 and p16 genes in the cellular response to Ultraviolet light. Role of the p16 tumor suppressor gene in cancer.
Liggett WH Jr(1), Sidransky D. Author information: (1)Department of Otolaryngology-Head and Neck Surgery and The Johns Hopkins Oncology Center, Johns Hopkins Hospital, Baltimore, MDby: In summary, many commonly lost tumor-suppressor genes, including p53, p16INK4A, and RB, play roles in the DDR- and DNA-repair pathways.
As summarized in this chapter, p53 acts as a central, versatile and multifunctional player in the cellular DDR. In response to DNA damage, p53 protein levels are upregulated, Cited by: 2. Wild type BJ cells (WT p53) retain a functional p53 pathway and is responsive to DNA damage response through p In this study, we knocked down p53 in BJ cells (shp53) in order to evaluate the role that p53 plays in ZnO nanoparticles induced DNA damage.
Materials and methods Characterization of ZnO nanoparticlesCited by: Given that p53 is a tumor suppressor that plays a central role in the cellular response to DNA damage and that more than 50% of all cancers have mutated p53, the wider utility of photodynamic.
The p21 tumor suppressor protein is activated in response to different DNA damaging agents and is the effector of p53 in the ionizing radiation-mediated signaling route. However, the role of p21 and p53 in the UV-dependent signaling pathway remains by: Cellular senescence is a permanent cell cycle arrest and a potent tumor suppression mechanism.
The p53 tumor suppressor is a sequence-specific transcription factor and acts as a central hub sensing various stress signals and activating an array of target genes to Cited by: p53 is a tumor suppressor protein that regulates the cell cycle and thus functions as a tumor suppressor that is involved in preventing cancer.
Activated p53 binds to the G1-S/CDK (CDK2) and S/CDK complexes (molecules important for the G1/S transition in the cell cycle) inhibiting their activity. By contrast, the products of tumor suppressor genes and DNA maintenance genes are not targets for anticancer drug development.
These two classes of gene cause cancer by not making their product. Thus, there is no abnormal product to be inhibited in cancer cells that arise by mutation of tumor suppressor or DNA maintenance genes.
The tumor-suppressive function of p53 can be attributed in part to its participation in the cellular response to DNA damage. In response to DNA strand breaks or transcription blocking DNA damage, such as UV light–induced photoproducts, p53 accumulates through a posttranscriptional mechanism (Levine, ; Ljungman, ).
kinase inhibitors, are the products of two tumor suppressor genes that play important roles in various cellular metabolic pathways. p21WAF1 is up-regulated in response to different DNA damaging. Analysis of the P53, RB/D13S25, and P16 Tumor Suppressor Genes in Marginal Zone B-cell Lymphoma: An Interphase Fluorescence In Situ Hybridization Study Author links open overlay panel J Dierlamm a M Stefanova a b I Wlodarska b K Hinz a B Maes c L Michaux b M Stul a b G Verhoef d J Thomas e C De Wolf-Peeters c H Van den Berghe b D.K Hossfeld a A Cited by: Ultraviolet radiation induces p16(CDKN2A) expression in human skin roles of the tumor suppressor, p53, in damage-induced cell cycle.
Ultraviolet B light induces. In the present study, we sought to investigate the role of p16 in apoptosis induced by ultraviolet light (the most important etiological cause of skin cancer) and cisplatin (an anticancer DNA Cited by: p53 also known as cellular tumor antigen p53 or phosphoprotein p53 or tumor suppressor p53 is a protein that in humans is encoded by the TP53 gene.
The p53 protein is crucial in multicellular organisms, where it regulates the cell cycle and, thus, functions as a tumor suppressor. Kaczmarek L, Oren M, Baserga R () Co-operation between the p53 protein tumor antigen and platelet-poor plasma in the induction of cellular DNA synthesis.
Exp Cell Res – PubMed CrossRef Google ScholarCited by: 2. Model illustrating the involvement of the p16, p53, and p21 tumor suppressors in senescence of human fibroblast cultures .
In pproficient (normal) fibroblasts, telomerase shortening (e.g., as a function of culture age) or exposure to DNA-damaging Cited by: P16 INK4A (also known as P16 and MTS1), a protein consisting exclusively of four ankyrin repeats, is recognized as a tumor suppressor mainly due to the prevalence of genetic inactivation of the p16 INK4A (or CDKN2A) gene in virtually all types of human cancers.
However, it has also been shown that elevated expression (up-regulation) of P16 is involved in cellular senescence, Cited by: p16 INK4A and p53 are two major tumor suppressor proteins that are both upregulated in response to various cellular stresses and during senescence and aging. p53 is a well-characterized transcription factor, while p16 INK4A a cyclin-dependent kinase inhibitor encoded by the CDKN2A gene, and controls the expression of several genes through protein–protein interactions and also via by: 5.
Abstract. p16 INK4a and p21 WAF1, two major cyclin-dependent kinase inhibitors, are the products of two tumor suppressor genes that play important roles in vCited by: Role of p16INK4A in Replicative Senescence and DNA Damage-Induced Premature Senescence in pDeficient Human cence and tumor suppressor gene p16 Cellular senescence plays a role.Here we provide an overview of the fundamental role of DDR in tumorigenesis and cellular senescence, under the light of the Yin-Yang concept of Chinese philosophy.
such as p53 or p16, the tumor suppressive role of p21 is not viewed as crucial. C.X.; Scott, F. Role of the tumor suppressor gene BRCA1 in genetic stability and mammary gland Cited by: 4.